YRDC's role in liver cancer growth and metabolism
Regulation of one-carbon metabolism and purine synthesis by YRDC in hepatocellular carcinoma
This project looks at whether lowering YRDC activity can slow hepatocellular carcinoma by cutting off the building blocks cancer cells need.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11251304 on NIH RePORTER |
What this research studies
Researchers are studying how the protein YRDC affects metabolism in hepatocellular carcinoma (HCC) cells. They will use lab models and metabolic methods such as metabolomics and isotope tracing to track one-carbon metabolism and purine production. The team will reduce YRDC levels in cancer cells to see if that limits tumor growth or changes response to chemotherapy. Results may point to ways to target YRDC or related pathways in future treatments.
Who could benefit from this research
Good fit: Patients with hepatocellular carcinoma who are willing to donate tumor tissue, blood samples, medical records, or join future clinical trials would be most relevant.
Not a fit: People without liver cancer or those whose tumors are driven by unrelated mechanisms may not see direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could lead to new therapies that slow or stop liver tumor growth by targeting cancer cell metabolism.
How similar studies have performed: Targeting cancer metabolism has shown promise in other cancers, but YRDC itself is a novel target with limited prior clinical testing.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Ali, Eunus — University of Kentucky
- Study coordinator: Ali, Eunus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.