Young blood factors to help aging bodies and brains recover
Reparative effect of juvenile factors in aging and injury
['FUNDING_R01'] · AUGUSTA UNIVERSITY · NIH-11299466
This project explores whether tiny particles from young blood can help older adults' bodies and brains recover better after severe bleeding and in Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-11299466 on ClinicalTrials.gov |
What this research studies
Researchers will use mouse models to test whether plasma components from young animals (small particles called extracellular vesicles) can improve recovery after severe blood loss and reduce age-related damage. They will give these juvenile plasma particles to adult and old mice after hemorrhagic shock and measure survival, organ function, mitochondrial health, and oxidative stress. The team will also treat a mouse model of Alzheimer's disease (5XFAD) to see if the young plasma particles reduce brain pathology. Molecular studies will try to identify the protective pathways so findings could guide future human therapies.
Who could benefit from this research
Good fit: People who might ultimately benefit include older adults at risk of severe bleeding-related injury and adults with early Alzheimer's disease or mild cognitive impairment.
Not a fit: This research focuses on aging and blood-loss injury and may not directly help children, pregnant people, or those with conditions unrelated to aging or trauma.
Why it matters
Potential benefit: If successful, this work could point to new therapies using young blood-derived factors to boost recovery after injury and slow Alzheimer-related brain changes in older adults.
How similar studies have performed: Earlier animal studies, including the investigators' own work, showed juvenile plasma extracellular vesicles improved organ function and survival after hemorrhagic shock in mice, but applying this to Alzheimer's and humans is new.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAJU, RAGHAVAN PILLAI — AUGUSTA UNIVERSITY
- Study coordinator: RAJU, RAGHAVAN PILLAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia