Withdrawal from ultra-processed foods

A Biopsychobehavioral Investigation of Withdrawal from Ultra-Processed Food in Humans

NIH-funded research University of Michigan at Ann Arbor · NIH-11119006

This project looks at whether people who cut back on ultra-processed foods experience withdrawal symptoms and stronger cravings.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor NIH-funded
Lab location1 site (Ann Arbor, United States)
Project IDNIH-11119006 on NIH RePORTER

What this research studies

If you regularly eat a lot of packaged, industrially produced foods, researchers will ask some participants to reduce or stop those foods and will track changes over time. They will record physical, thinking, and mood symptoms and test how much food-related cues (like images or smells) grab attention during abstinence. The work builds on animal findings by using human participants to see if withdrawal-like responses occur and whether those responses make it harder to keep eating fewer ultra-processed foods. Findings will be used to design better supports for people trying to change their diets.

Who could benefit from this research

Good fit: Ideal candidates are adults who regularly consume high amounts of ultra-processed foods and are willing to try reducing those foods under study conditions.

Not a fit: People who already avoid ultra-processed foods, or whose diets must be medically restricted, are unlikely to gain direct benefit from participating.

Why it matters

Potential benefit: If true, this could explain why cutting ultra-processed foods is hard and lead to new supports or treatments to help people stick with healthier diets.

How similar studies have performed: Animal studies have shown withdrawal-like effects from ultra-processed diets, but human evidence is limited, so this approach is relatively new in people.

Where this research is happening

Ann Arbor, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.