Wisconsin Alzheimer's Prevention Registry
Wisconsin Registry for Alzheimer's Prevention
Following middle-aged adults at higher risk to spot early brain changes, memory shifts, and how genes and lifestyle affect Alzheimer's risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11306649 on NIH RePORTER |
What this research studies
You would join a long-term registry that has followed people who enrolled in midlife and comes back for regular check-ins every two years. During visits you may do memory tests, complete health and lifestyle questionnaires, give blood for biomarker tests, and sometimes have brain imaging such as amyloid PET. The team combines your genetic, medical, and biomarker data to estimate when Alzheimer's protein changes begin and how memory changes over time. They also study how vascular health and lifestyle choices can speed up or slow cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates are adults in midlife (often around their 50s) who can attend periodic in-person visits and are willing to provide medical history, blood samples, and cognitive testing, especially those with a family history of Alzheimer's.
Not a fit: People with advanced Alzheimer's dementia or those unable to travel for in-person visits are unlikely to benefit from this prevention-focused registry.
Why it matters
Potential benefit: Could help identify early signs of Alzheimer’s well before symptoms appear and guide earlier prevention or personalized care strategies.
How similar studies have performed: Other long-term cohorts like ADNI have successfully tracked biomarkers and cognitive change, and newer plasma biomarker methods to time amyloid onset show promising early results.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Kirkland Caldwell, Jessica — University of Wisconsin-Madison
- Study coordinator: Kirkland Caldwell, Jessica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.