Wide-field 3D imaging of the cornea for better eye care
Official title: Wide-field three-dimensional high-resolution imaging of the cornea
Funded at University of Colorado · NIH-11523507 · Data updated 2026-11-12
A new imaging method aims to capture ultra-clear, three-dimensional pictures of the human cornea in living patients to help eye doctors diagnose and monitor corneal diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $64,800 |
| NIH project number | 3R21EY037083-02S1 |
| Project ID | NIH-11523507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (ages 21+) undergoing eye examinations who may benefit from enhanced corneal imaging.
✕Less likely to help
Individuals without corneal concerns or those unable to participate due to other medical or logistical reasons may not directly benefit.
What this research studies
This project explores a high-resolution, non-contact imaging technique that combines wide field of view with 3D and polarization sensitivity to visualize corneal structures in vivo. Researchers will develop and test speckle illumination holographic imaging to achieve confocal-like detail while making the method practical for everyday clinic use. The work focuses on translating advanced optics into a device that eye care providers can integrate into routine exams, potentially improving detection of corneal problems. Over time, the technique could offer clinicians a new tool to better understand corneal health and guide treatment decisions.
Why it matters
Potential benefit: If successful, patients could benefit from more accurate, non-invasive corneal imaging during regular eye exams, leading to earlier diagnosis and better management of corneal diseases.
How similar studies have gone: Previous imaging techniques improved corneal visualization but this project aims to push resolution and field of view beyond current methods in a clinical setting.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Piestun, Rafael — University of Colorado
- Study coordinator: Piestun, Rafael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.