Why viral infections worsen non‑type‑2 asthma in children and adults
Project-002
This project looks at how common cold viruses change airway cells from children and adults with non‑type‑2 asthma to find new treatment targets.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11327273 on NIH RePORTER |
What this research studies
Researchers will collect bronchial airway epithelial cells from well-characterized children and adults with and without asthma. They will grow these cells in organotypic ex vivo airway models and expose them to rhinovirus to measure interferons and non‑T2 cytokines such as IL‑1β, TNF‑α, IL‑17C, and G‑CSF. The team will compare responses between non‑T2 and T2‑high donors to understand how the epithelium drives viral-triggered exacerbations, persistent inflammation, and changes in lung function. Results are intended to identify epithelial mechanisms that could be targeted by new therapies for non‑T2 asthma.
Who could benefit from this research
Good fit: Ideal participants are children and adults with non‑T2 asthma who have poor control or frequent viral-triggered exacerbations and are willing to provide bronchial airway samples.
Not a fit: People whose asthma is well controlled by current type‑2 targeted biologics or who have unrelated lung diseases are less likely to benefit directly.
Why it matters
Potential benefit: Could point to new treatments that prevent or lessen virus-triggered asthma attacks in people with non‑T2 asthma.
How similar studies have performed: Previous work has found altered interferon and cytokine responses in asthma, but applying organotypic airway models to pinpoint epithelial drivers in non‑T2 asthma is relatively new.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Hallstrand, Teal S — University of Washington
- Study coordinator: Hallstrand, Teal S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.