Why some people develop diabetes after acute pancreatitis
Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis
['FUNDING_U01'] · JOHNS HOPKINS UNIVERSITY · NIH-11234470
They will follow people who had acute pancreatitis to find clinical, imaging, and blood changes that signal higher risk of developing diabetes.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11234470 on ClinicalTrials.gov |
What this research studies
You'll be followed over time after an episode of acute pancreatitis with regular clinic visits, pancreas imaging, continuous glucose monitoring, and blood draws. The team is recruiting participants for the main DREAM study and two related projects: IMMINENT (pancreas imaging) and DREAM-ON (detailed metabolic monitoring using novel CGM metrics). Blood tests will look at beta cell function and immune markers, and a pilot lab study will search for pancreas-specific autoantigens and neoantigens. Data from symptoms, scans, lab tests, and wearable glucose monitors will be combined to learn who develops diabetes and why.
Who could benefit from this research
Good fit: Ideal candidates are people who recently experienced an episode of acute pancreatitis and are willing to attend follow-up visits, imaging, and blood sampling.
Not a fit: People without a history of acute pancreatitis or those with long-standing, established diabetes from other causes are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could identify people at high risk for diabetes after pancreatitis so they can receive earlier monitoring and treatment.
How similar studies have performed: Previous studies of diabetes after acute pancreatitis have shown mixed and inconsistent results, so this consortium-based effort aims to standardize methods and fill gaps.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGH, VIKESH — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SINGH, VIKESH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brittle Diabetes Mellitus