Why some people develop diabetes after acute pancreatitis
Official title: Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis
Funded at Johns Hopkins University · NIH-11234470 · Data updated 2026-11-12
They will follow people who had acute pancreatitis to find clinical, imaging, and blood changes that signal higher risk of developing diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 16, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $443,000 |
| NIH project number | 2U01DK127400-06 |
| Project ID | NIH-11234470 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people who recently experienced an episode of acute pancreatitis and are willing to attend follow-up visits, imaging, and blood sampling.
✕Less likely to help
People without a history of acute pancreatitis or those with long-standing, established diabetes from other causes are unlikely to benefit directly from this project.
What this research studies
You'll be followed over time after an episode of acute pancreatitis with regular clinic visits, pancreas imaging, continuous glucose monitoring, and blood draws. The team is recruiting participants for the main DREAM study and two related projects: IMMINENT (pancreas imaging) and DREAM-ON (detailed metabolic monitoring using novel CGM metrics). Blood tests will look at beta cell function and immune markers, and a pilot lab study will search for pancreas-specific autoantigens and neoantigens. Data from symptoms, scans, lab tests, and wearable glucose monitors will be combined to learn who develops diabetes and why.
Why it matters
Potential benefit: If successful, this work could identify people at high risk for diabetes after pancreatitis so they can receive earlier monitoring and treatment.
How similar studies have gone: Previous studies of diabetes after acute pancreatitis have shown mixed and inconsistent results, so this consortium-based effort aims to standardize methods and fill gaps.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Singh, Vikesh — Johns Hopkins University
- Study coordinator: Singh, Vikesh
Related research
Other NIH-funded projects on the same topics.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
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Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
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Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
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Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
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Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
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Epidemiology and causes of diabetes after acute pancreatitis
A long-term study following people who have had acute pancreatitis to understand how often diabetes develops, why it happens, and how it progresses.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.