Why some dengue antibodies make illness worse
Mechanisms of Antibody-Dependent Enhancement of Dengue Disease
['FUNDING_R01'] · ROCKEFELLER UNIVERSITY · NIH-11158664
This work checks whether certain antibodies in people who had dengue before can make later dengue infections more severe.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11158664 on ClinicalTrials.gov |
What this research studies
Researchers will study blood samples from people in dengue-endemic areas and people who previously had dengue to look at the exact types of antibodies they make. In the lab, they will test how those antibodies bind to immune-cell receptors and whether that helps the dengue virus infect those cells. They will pay special attention to small sugar changes on antibodies (like afucosylation) that change how antibodies interact with Fcγ receptors. The team combines patient sample analysis with cellular experiments to link antibody features to disease severity.
Who could benefit from this research
Good fit: People who have had dengue before or who live in dengue-endemic regions and can provide blood samples would be the most relevant participants.
Not a fit: People without prior dengue exposure, those not in endemic areas, or anyone needing immediate treatment for acute dengue are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this could guide safer vaccine and therapy designs that avoid producing antibodies that worsen dengue.
How similar studies have performed: Prior lab and population studies have linked certain antibody features to worse dengue outcomes, but applying that knowledge to treatments or safer vaccines is still at an early stage.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOURNAZOS, STYLIANOS — ROCKEFELLER UNIVERSITY
- Study coordinator: BOURNAZOS, STYLIANOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.