Why some children develop type 2 diabetes during puberty
Metabolic, behavioral and social determinants of youth-onset T2D
['FUNDING_U01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11289380
Researchers will follow kids through puberty to find which biological changes, behaviors, and social factors raise the chance of developing type 2 diabetes.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11289380 on ClinicalTrials.gov |
What this research studies
This study follows children and adolescents over time, tracking growth, body measurements, blood sugar, insulin and beta‑cell function, and questions about behavior and social context. Participants will have regular clinic visits, blood tests, and surveys so researchers can map how changes during puberty relate to diabetes risk. The project compares youth who stay healthy with those who move from normal blood sugar to prediabetes or type 2 diabetes to pinpoint when and why problems start. The study includes boys and girls and aims to include different communities to understand geographic and population differences.
Who could benefit from this research
Good fit: Children and teenagers going through puberty—especially those overweight/obese or with a family history of type 2 diabetes—are the most likely candidates for participation.
Not a fit: Adults, very young children not yet approaching puberty, or people already well past initial diabetes development are unlikely to benefit directly from this study.
Why it matters
Potential benefit: Findings could help spot at-risk youth earlier and guide new ways to prevent or treat youth-onset type 2 diabetes.
How similar studies have performed: Previous cohort studies have linked obesity and puberty to diabetes risk, but this longitudinal effort that combines biology, behavior, and social context is broader and more focused on underlying mechanisms than most past work.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ISASI, CARMEN R. — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: ISASI, CARMEN R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus