Why middle-aged people are dying more in some U.S. places

Geographic Trends And Disparities In Psychosocial Wellbeing, Health Behaviors, And Mortality In Midlife

NIH-funded research Syracuse University · NIH-11321537

This project looks at whether state and county policies and local economic conditions relate to rising deaths and risky behaviors among middle-aged adults across the United States.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionSyracuse University NIH-funded
Lab location1 site (Syracuse, United States)
Project IDNIH-11321537 on NIH RePORTER

What this research studies

From your perspective, researchers are linking state laws, county economic data, death records, and health surveys to see where and why deaths among middle-aged adults are increasing. They will focus on causes that drive the trend—suicide, drug overdose, alcohol-related deaths, and cardiometabolic diseases—and compare regions like the Midwest, South, rural areas, and small cities. The team will analyze how state policies and county conditions act together, rather than looking at each separately. The goal is to identify community and policy factors that could be changed to help reduce these deaths.

Who could benefit from this research

Good fit: The focus is on adults in midlife (roughly ages 35–64) living in U.S. counties, especially in Midwestern, Southern, rural, and small-city areas.

Not a fit: Young people, children, people outside the United States, or individuals seeking immediate clinical treatment are unlikely to see direct benefits from this population-level research.

Why it matters

Potential benefit: If successful, the findings could guide state and local policies and community programs to lower suicide, overdose, alcohol-related, and heart-related deaths in middle-aged adults.

How similar studies have performed: Prior research has shown rising midlife mortality and geographic patterns tied to economic distress and policy differences, but this study's combined state-and-county approach adds new analysis to unresolved questions.

Where this research is happening

Syracuse, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.