Why cell division 'clocks' stay steady
Understanding the robustness of cell cycles
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11261737
Researchers are using computer models and tiny lab-made cell droplets to learn how the 'clocks' that control cell division stay steady, which matters for diseases like cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11261737 on ClinicalTrials.gov |
What this research studies
This project uses large-scale computer simulations to test how different network 'wiring' affects biological clock behavior. In the lab, scientists recreate mitotic cycles by encapsulating cell-free extracts in droplet-based microfluidic capsules to mimic single cells. They will compare computational predictions with results from these artificial cells and from animal embryos to identify features that keep oscillations robust. The work aims to uncover basic design rules behind stable cellular clocks and how they resist environmental changes.
Who could benefit from this research
Good fit: This grant does not enroll patients; it relies on computational work, cell-free droplet systems, and animal embryos rather than human volunteers.
Not a fit: People with active cancer should not expect direct or immediate benefits because the project does not offer clinical treatments or patient enrollment.
Why it matters
Potential benefit: If successful, this work could reveal fundamental principles that help researchers develop new ways to target cell-cycle problems in cancers and related conditions.
How similar studies have performed: Similar computational and cell-free oscillator experiments have improved understanding of biological clocks, but translating those findings into human cancer therapies remains early and exploratory.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, QIONG — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: YANG, QIONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers