Why cancer spreads: the genes and biology behind metastasis
Biology and genetics of metastatic disease
This project looks at how inherited genes and cell signals, including the ApoE protein, change whether solid tumors spread to other parts of the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11159528 on NIH RePORTER |
What this research studies
You would learn that the team studies molecules like microRNAs and the ApoE protein that can change how tumors grow and spread. They combine analysis of human genetic data and tumor samples with lab models to see how these changes affect blood vessels, immune responses, and tumor cell invasiveness. The researchers found common APOE gene variants that can make some cancers more or less likely to form metastases and are using that knowledge to guide treatments aimed at metastasis. Early clinical testing inspired by this work has shown some tumor regression in advanced patients.
Who could benefit from this research
Good fit: People with solid tumors at high risk of spreading (for example advanced breast cancer or melanoma) or anyone willing to donate blood or tumor samples for research.
Not a fit: Patients with cancers unrelated to the pathways being studied or those who cannot provide samples or travel to participating centers may not receive direct benefit from this work.
Why it matters
Potential benefit: Could lead to treatments that stop or shrink metastases, improving survival and outcomes for people with solid tumors.
How similar studies have performed: Preclinical studies and early clinical tests targeting metastasis-related pathways, including ApoE-informed approaches, have shown promising responses but the strategy remains an emerging area.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Tavazoie, Sohail F. — Rockefeller University
- Study coordinator: Tavazoie, Sohail F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.