Whole Protein Antibody Profiling to Understand Type 1 Diabetes Triggers
Official title: Whole Protein Arrays to Detect Antimicrobial Antibodies Associated with Triggering and Progression of Islet Autoimmunity in TEDDY
Funded at Arizona State University-Tempe Campus · NIH-11401115 · Data updated 2026-11-12
Researchers will use comprehensive protein arrays to map antibodies against microbes in children from the TEDDY study to understand what environmental factors may trigger Type 1 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $973,632 |
| NIH project number | 5R01DK140781-03 |
| Project ID | NIH-11401115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children enrolled in the TEDDY cohort who have accessible biosamples and data on autoimmune markers.
✕Less likely to help
Individuals outside the TEDDY cohort or lacking relevant biosamples may not directly benefit.
What this research studies
This project uses advanced immunoproteomics to screen antibodies against many microbes in blood samples from a large birth cohort. It combines high-throughput protein arrays with detailed statistical analyses to link antibody patterns with the development of islet autoimmunity and Type 1 diabetes. The goal is to build a holistic view of environmental triggers beyond traditional candidate microbes, with findings that could guide prevention efforts. The study is anchored in the long-running TEDDY cohort and involves a multidisciplinary team across diabetes, virology, metagenomics, and data science. By identifying antibody responses to viral and other microbial antigens, the research aims to illuminate pathways leading to autoimmune attack on the pancreas.
Why it matters
Potential benefit: If successful, the work could reveal infectious triggers or protective factors for Type 1 diabetes, informing prevention strategies.
How similar studies have gone: Prior high-throughput serology work has identified associations between infections and autoimmunity, but this study expands breadth and depth with proteome-wide arrays and prospective data.
Where this research is happening
-
Arizona State University-Tempe Campus
Scottsdale, United States Active
Researchers
- Principal investigator: Labaer, Joshua — Arizona State University-Tempe Campus
- Study coordinator: Labaer, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.