Whole inactivated vaccine for EV-D68 infection
Official title: Efficacy of a whole inactivated vaccine against EV-D68 infection
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11353078 · Data updated 2026-11-12
A new vaccine candidate is being developed to protect people from EV-D68, a virus that can cause serious respiratory illness and polio-like symptoms in children.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | May 22, 2026 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $223,728 |
| NIH project number | 1R21AI199351-01 |
| Project ID | NIH-11353078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals at risk for EV-D68 exposure, including children and adults with ARDS or related risk factors.
✕Less likely to help
People without exposure risk or those who cannot be vaccinated for medical reasons may not benefit.
What this research studies
This project aims to create a whole inactivated vaccine against EV-D68 and test whether it can prevent acute respiratory illness and polio-like muscle weakness. Researchers will use a novel method to preserve key antibody targets that help neutralize the virus. The work includes preclinical and early-phase assessment to see if the vaccine can reduce disease severity and prevent nerve-related complications. If successful, the findings could pave the way for a vaccine that protects children and others at risk.
Why it matters
Potential benefit: If successful, the vaccine could reduce EV-D68 illness and prevent severe respiratory or neurological outcomes in vulnerable populations.
How similar studies have gone: Previous work with inactivated vaccines against EV-D68 shows promise, but no licensed EV-D68 vaccine exists yet.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Mattapallil, Joseph John — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Mattapallil, Joseph John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.