Who is most likely to get heart rhythm problems from medicines
Predicting determinants of susceptibility to drug-induced arrhythmias
This project will create lab and computer tools to predict which people are likely to have dangerous heart rhythm problems caused by certain drugs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11233296 on NIH RePORTER |
What this research studies
Researchers are using heart cells grown from stem cells to see how different drugs change electrical signals and calcium inside the cells. They will tune detailed computer models with those lab measurements and run simulations that mimic differences between people. Machine learning will combine lab and simulation results to produce predictive tools for individual risk. The team aims to identify traits or conditions that make someone more vulnerable to drug-induced arrhythmias.
Who could benefit from this research
Good fit: People who have had arrhythmias, inherited rhythm disorders, or who take medicines known to affect heart rhythm would be the most likely to benefit or be asked to provide samples.
Not a fit: People whose symptoms are due to structural heart disease or other non-drug causes may not receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this work could help doctors avoid prescribing medicines that would trigger dangerous arrhythmias in people at higher risk.
How similar studies have performed: Laboratory tests and mechanistic models have improved drug-safety screening recently, but using them to predict individual patient risk is still a relatively new approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Sobie, Eric a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Sobie, Eric a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.