When different kinds of asthma develop in high-risk toddlers
Critical Windows in the Development of Asthma Endotypes and Phenotypes in High-Risk Toddlers
This project follows young, high-risk children over time to map how different asthma types and lung problems appear so doctors can find ways to prevent persistent asthma.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11319843 on NIH RePORTER |
What this research studies
If my toddler has repeated wheeze, this project will enroll them and follow them for four years to see how airway biology and lung function change over time. They recruit toddlers aged 1.5–3 years from urban, low-income families who have had at least three wheezing or asthma episodes requiring treatment. Each year children will have airway samples taken for molecular 'endotyping' and will undergo lung function testing to track steps that lead to persistent asthma. By pinpointing when and how airway changes occur, the team hopes to identify targets and timing for future prevention strategies.
Who could benefit from this research
Good fit: Toddlers about 1.5–3 years old from urban, low-income families who have experienced at least three wheezing or asthma episodes requiring treatment are the intended participants.
Not a fit: Children without recurrent wheeze, older children, or those unable to attend clinic visits are unlikely to be enrolled or to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could reveal early markers and timing for interventions that help prevent children from developing persistent asthma.
How similar studies have performed: Prior work has identified asthma endotypes (for example, T2-high) and enabled targeted treatments for some patients, but long-term early-life molecular mapping in high-risk toddlers is a relatively new approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Liu, Andrew H — University of Colorado Denver
- Study coordinator: Liu, Andrew H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.