What role do macrophage enzymes play in fat tissue health and obesity-related inflammation?

Who could benefit from this research

What this research studies

Scientists will use mouse models with precise gene editing to turn off specific transglutaminase enzymes in different cell types within fat tissue. They will also test a new method to delete genes in a controlled, time-specific way to see how these enzymes influence fat cell growth, immune cell behavior, and the surrounding matrix. The goal is to understand how these enzymes contribute to inflammation, tissue remodeling, and metabolism, with an eye toward preventing or reversing type 2 diabetes linked to obesity. Findings could guide new therapies that target immune-fat interactions to improve glucose control.

Why it matters

Where this research is happening

• University of Maryland Baltimore County
  Baltimore, United States Active

Researchers

• Principal investigator: Elizondo, Diana Margarita — University of Maryland Baltimore County
• Study coordinator: Elizondo, Diana Margarita

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.