What NSD3 does in lung squamous cell carcinoma
Role of NSD3 in regulation of cancer pathogenesis
This project looks at whether blocking the protein NSD3 can slow or stop lung squamous cell carcinoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11296885 on NIH RePORTER |
What this research studies
Researchers will study how the NSD3 protein changes gene activity in lung squamous cell carcinoma using mouse models and human cancer samples. They will map where NSD3 acts on the genome and measure the resulting changes in tumor growth and cell behavior. The team will also test drugs or approaches that reduce NSD3 activity to see if tumors respond. The overall aim is to find actionable targets that could lead to new treatments for this hard-to-treat lung cancer.
Who could benefit from this research
Good fit: People with lung squamous cell carcinoma, especially those whose tumors show NSD3 changes or who are interested in donating tumor tissue for research, could be relevant to this work or future trials.
Not a fit: Patients with other types of lung cancer or cancers not driven by NSD3 alterations are less likely to benefit directly from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new targeted therapies that slow tumor growth or improve outcomes for people with lung squamous cell carcinoma.
How similar studies have performed: Other epigenetic-targeting approaches have shown promise in lab and early-phase work, but targeting NSD3 specifically is a relatively new and experimental direction.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Mazur, Pawel K. — University of Tx Md Anderson Can Ctr
- Study coordinator: Mazur, Pawel K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.