What makes melanoma cells spread early
Project 1: Tumor Cell Intrinsic Determinants of Early Dissemination in Melanoma
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11143041
Researchers are looking at features inside melanoma cells that let the cancer spread early, to help people with melanoma.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11143041 on ClinicalTrials.gov |
What this research studies
You would have tumor cells examined to see different gene activity and cell states that might cause early spread. The team will map transcriptional and epigenetic patterns in primary melanomas and track how those cell states change over time. They will combine molecular analyses with cell and animal models and tissue studies to trace which cells seed metastases. Results are intended to point to markers or targets to stop early dissemination.
Who could benefit from this research
Good fit: People with primary cutaneous melanoma, especially those with early-stage tumors or who can donate tumor tissue, would be most relevant.
Not a fit: People without melanoma or those with unrelated diseases are unlikely to get direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could lead to tests that predict which melanomas will spread early and to new ways to prevent or treat early metastasis.
How similar studies have performed: Previous studies have shown melanoma cell plasticity and heterogeneity relate to metastasis, but integrating these features to define early metastatic drivers is a newer, active area.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HERNANDO, EVA — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: HERNANDO, EVA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Candidate Disease Gene