What makes glioblastoma cells spread in the brain and how to stop them
Project 1
This project looks at how different types of glioblastoma move through brain tissue and interact with immune cells to find new treatment targets for people with glioblastoma.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11162511 on NIH RePORTER |
What this research studies
Researchers compare two glioblastoma subtypes that show different movement and force-generation behaviors. They use immune-competent, genetically engineered mouse models together with human tumor cells and advanced imaging (including two-photon microscopy) to watch tumor cells and T cells move in brain tissue. Engineering-style computational models will be used to manage complexity and identify the mechanical features that make tumors invasive or resistant to immune attack. The team aims to reveal mechanical weaknesses that could be targeted by future therapies.
Who could benefit from this research
Good fit: Adults with glioblastoma who could donate tumor tissue or be eligible for related future clinical trials are the most relevant candidates.
Not a fit: People without glioblastoma, with non-malignant brain conditions, or those seeking immediate treatment benefits are unlikely to gain direct benefit from this preclinical-focused project.
Why it matters
Potential benefit: If successful, this work could point to new ways to block tumor spread or help immune cells reach glioblastoma, potentially slowing disease progression.
How similar studies have performed: Laboratory studies have suggested tumor mechanics affect invasion and immune interactions, but translating these findings into effective human treatments remains largely unproven.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Odde, David J. — University of Minnesota
- Study coordinator: Odde, David J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.