What controls the making of red blood cells
Transcriptional Control During Erythropoiesis
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11300495
This project aims to map the proteins and 3D genome changes that control how red blood cells develop to help people with anemia and related blood disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11300495 on ClinicalTrials.gov |
What this research studies
Researchers will use single-cell methods to measure DNA accessibility, gene activity, cell surface markers, and protein levels of key transcription factors in human blood-forming cells. They will also study how the genome folds in three dimensions and how transcription factors interact with partner proteins to turn genes on or off. By integrating these measurements into an expanded gene regulatory network model, the team hopes to create a predictive map of erythropoiesis in health and disease. The work uses human cells and could include blood samples from people with conditions like anemia or beta-thalassemia.
Who could benefit from this research
Good fit: People with anemia, including inherited forms like beta-thalassemia, who can provide blood samples for research would be the most relevant participants.
Not a fit: People without blood disorders, or patients seeking immediate clinical treatment, are unlikely to receive direct benefit from this basic research.
Why it matters
Potential benefit: If successful, this work could point to new diagnostics or treatment targets for anemias such as beta-thalassemia.
How similar studies have performed: Earlier work produced detailed single-cell gene networks for erythropoiesis, but adding direct protein measurements and 3D genome organization is a novel advance.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRAND, MARJORIE CAROLE — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BRAND, MARJORIE CAROLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.