What controls cell identity in lung adenocarcinoma
Transcriptional Regulation of Lung Cancer Identity
This project looks at how specific genes and cancer signals change the identity and behavior of lung adenocarcinoma cells to help people with this cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11235929 on NIH RePORTER |
What this research studies
If you have lung adenocarcinoma, this research aims to explain why tumor cells take on different identities that affect prognosis and treatment response. The team will use genetically engineered mice, lab-grown organoids (mini-tumors), patient-derived tumor grafts and cell lines to model those identities. They will focus on gene regulators such as FoxA1/2 and NKX2-1 and test clinically relevant drugs that alter signaling pathways. Findings are meant to point toward ways to make tumors more treatable or prevent drug resistance.
Who could benefit from this research
Good fit: People with lung adenocarcinoma who can provide tumor tissue (for example at surgery or biopsy) for research use would be the ideal contributors to this work.
Not a fit: Patients without lung adenocarcinoma or those unable or unwilling to provide tumor tissue are unlikely to see a direct benefit from participating.
Why it matters
Potential benefit: Could lead to new ways to steer tumor cells into states that respond better to treatment or avoid resistance.
How similar studies have performed: Prior laboratory studies have shown that lineage factors like NKX2-1 and FoxA proteins shape lung tumor behavior, but turning those findings into patient therapies is still early.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Snyder, Eric Lee — Utah State Higher Education System--University of Utah
- Study coordinator: Snyder, Eric Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.