Vitamin D and Colorectal Cancer Survival
Leveraging Novel Randomized Clinical Trials of Vitamin D Supplementation in Patients with Colorectal Cancer: Impact on Survival and Anti-Tumor Immunity
This research explores if taking vitamin D supplements can help people with colorectal cancer live longer and boost their body's ability to fight the cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11135575 on NIH RePORTER |
What this research studies
We know that vitamin D might help fight cancer, and people with higher vitamin D levels often have better outcomes with colorectal cancer. This project aims to find out if taking vitamin D supplements directly improves survival for patients with colorectal cancer. We are conducting two main studies: one for patients with advanced colorectal cancer receiving chemotherapy, and another for patients with liver metastases before surgery. We also want to understand how vitamin D might strengthen the body's immune response against tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research would be patients with metastatic colorectal cancer or those with resectable liver metastases from colorectal cancer.
Not a fit: Patients without colorectal cancer or those not fitting the specific trial criteria for metastatic or resectable liver disease may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this research could show that vitamin D supplementation is a simple and effective way to improve survival for patients with colorectal cancer.
How similar studies have performed: Previous laboratory and population studies suggest a link between vitamin D and better colorectal cancer outcomes, and a prior Phase II trial showed promising results, leading to this larger Phase III effort.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Ng, Kimmie — Dana-Farber Cancer Inst
- Study coordinator: Ng, Kimmie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.