Viruses and immune changes linked to type 1 diabetes in children
Virome and Immune Responses associated with IA and Type 1 Diabetes
Researchers will look at viruses and immune responses in samples from young children to find whether long-lasting enterovirus infections are linked to early islet autoimmunity and type 1 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11295390 on NIH RePORTER |
What this research studies
This project analyzes stored blood cells, nasal swabs, stool, and plasma from 450 children enrolled in the TEDDY study to look for prolonged enterovirus infections and related immune changes. Labs will use PCR, ampliseq, and detailed single-cell multi-omic techniques to detect viruses and map immune cell responses over time. The team will compare children who developed islet autoimmunity or type 1 diabetes by age 6 with those who did not to identify patterns linked to disease. Because the work uses previously collected samples, it does not require new procedures from participants.
Who could benefit from this research
Good fit: Ideal candidates are children from the TEDDY cohort with stored blood, nasal swab, stool, or plasma samples, especially those who developed islet autoimmunity or type 1 diabetes by age 6.
Not a fit: Children or adults not enrolled in TEDDY and those without stored samples are unlikely to be included or to receive direct benefit from this specific project.
Why it matters
Potential benefit: If successful, the work could reveal viral causes and immune markers that help predict, prevent, or better understand type 1 diabetes in children.
How similar studies have performed: Previous TEDDY analyses have suggested links between prolonged enterovirus infections and islet autoimmunity, while the single-cell immune profiling planned here is a newer, more detailed approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lloyd, Richard E — Baylor College of Medicine
- Study coordinator: Lloyd, Richard E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.