Virtual esophagus to predict surgery results for reflux and swallowing problems
vEsophagus - Predicting surgical outcomes using a virtual esophagus
This project builds a computerized 'virtual esophagus' that uses your medical test results to predict how well surgery might help adults with reflux or swallowing problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11260173 on NIH RePORTER |
What this research studies
This work uses common clinical tests (endoscopy, high-resolution manometry, esophagram, and impedance) to collect anatomical and physiologic data about the esophagus. Those measurements feed a physics-based computer model that simulates how a swallowed bolus moves through your esophagus. Investigators will use the model to predict how different surgical options could change bolus transit and symptoms. The goal is to help doctors personalize treatment and avoid unnecessary invasive procedures.
Who could benefit from this research
Good fit: Adults (21+) with esophageal motility disorders such as achalasia or with gastroesophageal reflux disease (GERD) who have recent diagnostic testing and are considering surgical treatment are the most likely candidates.
Not a fit: People without esophageal motility or reflux problems, children under 21, or patients who lack the necessary diagnostic test data are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this could help predict who will benefit from esophageal surgery, guide choice of procedure, and reduce unnecessary or ineffective operations.
How similar studies have performed: Physics-based esophageal models have shown promise in pilot and translational work over the past decade, but they are not yet widely adopted in routine clinical care.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Patankar, Neelesh a. — Northwestern University
- Study coordinator: Patankar, Neelesh a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.