Vascular changes in early HIV and after starting treatment
Systemic and Central Nervous System Vasculopathy in Acute HIV and After Early Antiretroviral Therapy
This project looks at blood vessel and brain blood-flow changes in people who recently got HIV, before and after they start antiretroviral treatment.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11386705 on NIH RePORTER |
What this research studies
This research follows people who began HIV treatment very soon after infection and checks blood vessel and brain vessel health over time. The team uses a well-established longitudinal cohort (SEARCH010/RV254) of participants in Thailand, collects blood samples, vascular tests, and brain imaging, and tracks cognitive symptoms. They compare measures taken during acute infection and after early ART to see whether vascular injury progresses despite treatment. The researchers aim to identify early markers linked to later stroke risk or cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed with HIV very shortly after infection who begin antiretroviral therapy within about 30 days of acquiring HIV.
Not a fit: People with long-standing, well-controlled HIV who started ART years ago or individuals without HIV are unlikely to directly benefit from this specific project.
Why it matters
Potential benefit: If successful, the work could reveal early signs of blood-vessel injury that help doctors prevent strokes and cognitive problems in people with HIV.
How similar studies have performed: Prior studies have shown vascular dysfunction in people with chronic HIV, but studying vascular changes during acute infection and immediately after early ART is relatively new.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Holroyd, Kathryn — Columbia University Health Sciences
- Study coordinator: Holroyd, Kathryn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.