Vanderbilt Center for Undiagnosed Conditions
Vanderbilt Center of Excellence for Undiagnosed Disease (VCEUD)
This program brings together doctors, genetic testing, and AI tools to help people with complex health problems that have not yet been diagnosed.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11158803 on NIH RePORTER |
What this research studies
You would have your medical history and tests reviewed by a team of specialists from pediatrics, neurology, immunology, genetics, and more, combined with genomic data and Vanderbilt's DNA databank. The program uses a tiered approach that starts with remote data review and moves to in-person testing when needed. Computer tools like bioinformatics and language-model methods are used alongside clinical exams to look for patterns or causes missed before. The center also works with community partners to reach diverse patients and trains new clinicians to sustain the effort.
Who could benefit from this research
Good fit: Ideal candidates are children or adults with complex, unexplained symptoms who have already had standard tests but still lack a diagnosis.
Not a fit: People with an established diagnosis, conditions outside the program's scope, or those unable to participate in required testing or visits may not benefit from this program.
Why it matters
Potential benefit: If successful, this could help people get a diagnosis, guide more targeted care, and inform better treatment for others with similar unexplained conditions.
How similar studies have performed: National undiagnosed disease networks have helped many patients receive diagnoses, and integrating AI tools is a newer approach with promising early results.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Hamid, Rizwan — Vanderbilt University Medical Center
- Study coordinator: Hamid, Rizwan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.