Vaginal dissolving films that deliver a contraceptive antibody (ZB-06)
Project 3: Film Formulation, PK/PD and Safety Studies of ZB-06
['FUNDING_OTHER'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-11168803
This work develops vaginal dissolving films that release a contraceptive antibody to prevent pregnancy in women.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11168803 on ClinicalTrials.gov |
What this research studies
If you join, researchers will create and test thin vaginal films that dissolve and release a human contraception antibody either immediately or over several days. Film formulations will be optimized in the lab and transferred for manufacturing under good-practice conditions before being used in clinical testing. Vaginal fluid samples will be collected to measure antibody levels and activity, and labs will check for safety signals such as inflammation, shifts in the vaginal microbiome, or new anti-sperm immune responses. The safety and drug-level information will be used to improve the films and guide future use.
Who could benefit from this research
Good fit: Sexually active women of reproductive age who want non-hormonal contraception and are willing to use the vaginal film and provide vaginal samples for testing.
Not a fit: People who are pregnant, trying to become pregnant, allergic to film components, or uninterested in a topical contraceptive are unlikely to benefit.
Why it matters
Potential benefit: Could provide a non-hormonal, on-demand or multi-day contraceptive option that works locally in the vagina.
How similar studies have performed: Vaginal films and local delivery have worked for other drugs and microbicides, but using an antibody for contraception is relatively new and early-stage.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDERSON, DEBORAH J — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: ANDERSON, DEBORAH J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.