Vaccines that help the immune system fight HIV
Official title: Self-amplifying mRNA-based vaccines to elicit VRC01-class bnAbs
Funded at Fred Hutchinson Cancer Center · NIH-10996122 · Data updated 2026-11-12
This study is looking at a new type of vaccine that helps your body make stronger defenses against HIV by training your immune system to recognize the virus better, and it's aimed at people interested in better protection against HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 30, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,415,922 |
| NIH project number | 5U19AI174242-03 |
| Project ID | NIH-10996122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for HIV or those who are HIV-negative and interested in participating in vaccine trials.
✕Less likely to help
Patients who are already HIV-positive or those with compromised immune systems may not benefit from this research.
What this research studies
This research investigates self-amplifying mRNA vaccines designed to stimulate the immune system to produce specific antibodies against HIV. The approach involves two immunogens that target B cell receptors, enhancing their ability to recognize and respond to the virus. Initially, one immunogen activates naïve B cells, while the second boosts the response of already activated B cells. If successful, this could lead to more effective vaccines against HIV.
Why it matters
Potential benefit: If successful, this research could lead to the development of a more effective vaccine against HIV, potentially reducing the incidence of the virus.
How similar studies have gone: Previous research has shown promise in using mRNA technology for vaccines, particularly in the context of infectious diseases, indicating potential for success in this novel approach.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Stamatatos, Leonidas — Fred Hutchinson Cancer Center
- Study coordinator: Stamatatos, Leonidas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.