Using young liver cells to rejuvenate older livers
Heterochronic hepatocyte transplantation to rejuvenate the aged liver
['FUNDING_R21'] · DUKE UNIVERSITY · NIH-10987403
This study is looking at whether putting young liver cells into older livers can help improve their health and function, which could lead to new treatments for people facing age-related liver issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10987403 on ClinicalTrials.gov |
What this research studies
This research investigates how transplanting young liver cells into older livers can potentially reverse aging effects. By using a technique called heterochronic hepatocyte transplantation, the study aims to understand how young cells can influence the function and health of aged liver tissue. The approach includes comparing the effects of young and old liver cells on metabolism and overall liver function, with controls to ensure accurate results. Patients may benefit from insights into new treatments for age-related liver decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related liver dysfunction.
Not a fit: Patients with acute liver failure or those who are not experiencing age-related liver issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that rejuvenate liver function in older patients.
How similar studies have performed: Previous studies have shown promising results with young blood rejuvenating effects in animal models, suggesting potential for success in this novel approach.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHITE, JAMES P. — DUKE UNIVERSITY
- Study coordinator: WHITE, JAMES P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.