Using xylitol gum to improve brain development in children born to mothers with periodontal disease
Prevention of Developmental Delay and Xylitol (PDDaX) Study
This study is looking at whether chewing xylitol gum before getting pregnant or during early pregnancy can help babies develop better in their first six years, especially for families who might be at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11095962 on NIH RePORTER |
What this research studies
This research investigates whether chewing xylitol gum before conception or during early pregnancy can improve neurodevelopmental outcomes in children up to 6 years old. The study builds on previous findings from a large trial in Malawi, where the link between periodontal disease and preterm birth was explored. By evaluating the effects of xylitol gum on inflammation and its potential role in preventing developmental delays, the research aims to provide insights into effective interventions for at-risk populations. Participants will be monitored for neurodevelopmental progress using established diagnostic tools.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women or those planning to conceive, particularly in low- and middle-income countries where periodontal disease is prevalent.
Not a fit: Patients who are not pregnant or not planning to conceive, as well as those without periodontal disease, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved developmental outcomes for children born to mothers with periodontal disease, potentially reducing the incidence of neurodevelopmental delays.
How similar studies have performed: Previous research has shown promising results in using xylitol for dental health, but this specific approach to prevent neurodevelopmental delays is novel and has not been extensively tested.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Valentine, Gregory Charles — University of Washington
- Study coordinator: Valentine, Gregory Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.