Using whole genome sequencing to understand genetic factors in prostate cancer survival.
Official title: TO PROVIDE SEQUENCING SERVICES USING WHOLE GENOME SEQUENCING (GERMLINE FFPE) FOR NCI (KLEIN)
Funded at Johns Hopkins University · NIH-10949135 · Data updated 2026-11-12
This study is looking at how your genes might affect survival after prostate cancer surgery, especially for African American men, to help improve treatment and understanding of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 27, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $774,000 |
| NIH project number | 268201700006I-0-759202300008-1 |
| Project ID | NIH-10949135 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American men diagnosed with prostate cancer who have undergone radical prostatectomy.
✕Less likely to help
Patients who do not have prostate cancer or those who have not undergone radical prostatectomy may not benefit from this research.
What this research studies
This research focuses on providing advanced genomic services, specifically whole genome sequencing, to investigate genetic predictors of prostate cancer survival, particularly in African American patients who have undergone radical prostatectomy. The study is part of a larger collaboration between the National Cancer Institute and the National Human Genome Research Institute, leveraging state-of-the-art genomics and statistical genetics services. By analyzing genetic data, the research aims to uncover important insights that could enhance understanding and treatment of prostate cancer. The data generated will also be made available for further research through public databases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors influencing prostate cancer survival, potentially guiding personalized treatment strategies.
How similar studies have gone: Previous research has shown success in using genomic data to identify genetic predictors of cancer outcomes, indicating that this approach has the potential for meaningful advancements.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Doheny, Kim — Johns Hopkins University
- Study coordinator: Doheny, Kim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.