Using viruses to treat difficult wound infections
The impact of bacteriophage therapy on wound infection dynamics
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11012330
This study is exploring a new way to help people with stubborn wound infections by using special viruses that attack bacteria, combined with regular antibiotics, to make treatments more effective against tough germs that don’t respond to standard medicines.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11012330 on ClinicalTrials.gov |
What this research studies
This research investigates the use of bacteriophages, which are viruses that specifically target bacteria, to treat persistent wound infections caused by antibiotic-resistant pathogens. The approach focuses on combining these phages with traditional antibiotics to enhance their effectiveness against multidrug-resistant bacteria, particularly in wounds infected by Pseudomonas aeruginosa. By developing a mixture of phages and antibiotics, the research aims to create a more effective treatment strategy that minimizes the risk of antibiotic resistance. Patients with chronic or difficult-to-treat wounds may benefit from this innovative therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with chronic wounds infected by multidrug-resistant bacteria, particularly Pseudomonas aeruginosa.
Not a fit: Patients with wounds that are not infected or those with infections caused by bacteria that are not targeted by the phage therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients suffering from antibiotic-resistant wound infections.
How similar studies have performed: Previous research has shown promise in using bacteriophage therapy for treating antibiotic-resistant infections, indicating that this approach could be effective.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOZNIAK, DANIEL J — OHIO STATE UNIVERSITY
- Study coordinator: WOZNIAK, DANIEL J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-microbial resistant infection