Using vanadium complexes to improve carbon isotope exchange in drug development
Official title: Carbon isotope exchange mediated by vanadium complexes
Funded at Florida International University · NIH-10890828 · Data updated 2026-11-12
This study is exploring a new way to make drugs easier to study by using a special form of carbon, which could help scientists understand how medications work in the body and improve the process of developing new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $359,560 |
| NIH project number | 5R35GM150902-02 |
| Project ID | NIH-10890828 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals involved in clinical trials for new pharmaceuticals that utilize carbon-14 labeling for metabolic studies.
✕Less likely to help
Patients who are not participating in clinical trials or those not receiving medications that require carbon isotope tracking may not benefit from this research.
What this research studies
This research focuses on creating new catalysts using vanadium to facilitate the exchange of carbon isotopes in drug compounds. By incorporating carbon-14 isotopes directly into pharmaceuticals, the study aims to enhance metabolic and pharmacokinetic analyses, which are crucial for understanding how drugs behave in the body. The approach utilizes accessible labeled iodomethane as a carbon source and aims to simplify the synthesis of labeled compounds, making it easier to study their effects. This innovative method could lead to more efficient drug development processes.
Why it matters
Potential benefit: If successful, this research could significantly streamline the process of drug development by allowing for more accurate tracking of how medications are metabolized in the body.
How similar studies have gone: While the use of carbon isotopes in drug development is established, the specific application of vanadium-based catalysts for carbon isotope exchange is a novel approach that has not been widely tested.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Bukhryakov, Konstantin — Florida International University
- Study coordinator: Bukhryakov, Konstantin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.