Using Valsartan to Help Treat Pulmonary Hypertension
Official title: REVAMP-PH: REpurposing Valsartan May Protect against Pulmonary Hypertension
Funded at University of Washington · NIH-10953832 · Data updated 2026-11-12
This study is looking at whether Valsartan, a heart medication, can help people with pulmonary hypertension and right heart failure feel better and live healthier lives by improving how their right heart works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $753,917 |
| NIH project number | 4R33HL167848-02 |
| Project ID | NIH-10953832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are diagnosed with pulmonary hypertension and may be experiencing right heart failure.
✕Less likely to help
Patients with pulmonary hypertension who do not have right heart failure or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the potential of repurposing Valsartan, a medication commonly used for heart conditions, to improve outcomes for patients with pulmonary hypertension and right heart failure. The study aims to understand how targeting angiotensin receptors can benefit the right heart, which is often affected in these patients. By analyzing previous findings that suggest angiotensin receptor blockers may reduce mortality in pulmonary hypertension, the research seeks to establish a new treatment approach that could enhance patients' quality of life and daily functioning.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients suffering from pulmonary hypertension and related heart issues.
How similar studies have gone: Previous studies have shown promising results with angiotensin receptor blockers in similar patient populations, indicating a potential for success in this novel application.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Leary, Peter J — University of Washington
- Study coordinator: Leary, Peter J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.