Using vagal nerve stimulation to reduce pain and slow the progression of osteoarthritis
BCCMA: Targeting Osteoarthritis Pain and Progression: Preclinical OA models of vagal nerve stimulation to reduce pain and progression of OA
This study is looking at how a treatment called vagal nerve stimulation might help veterans with osteoarthritis pain and improve their joint health by understanding how their bodies respond to inflammation and stress on their joints.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma City VA Medical Center NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10948889 on NIH RePORTER |
What this research studies
This research investigates how vagal nerve stimulation (VNS) can help manage osteoarthritis (OA) pain and its progression, particularly in veterans who are disproportionately affected by this condition. The study aims to understand the biological responses of joint tissues to inflammation and mechanical stress, which may contribute to OA symptoms. By utilizing both clinical data from veterans and animal models, the research seeks to develop targeted therapies that can effectively alleviate pain and improve joint function. The approach combines laboratory findings with clinical applications to ensure that new treatments are grounded in real-world patient needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans suffering from osteoarthritis, particularly those experiencing chronic pain and disability.
Not a fit: Patients who do not have osteoarthritis or those who are not veterans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce pain and slow the progression of osteoarthritis in patients.
How similar studies have performed: Previous research has shown promising results with vagal nerve stimulation in other pain-related conditions, suggesting potential for success in this novel application.
Where this research is happening
Oklahoma City, United States
- Oklahoma City VA Medical Center — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Humphrey, Mary Beth — Oklahoma City VA Medical Center
- Study coordinator: Humphrey, Mary Beth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.