Using urinary extracellular vesicles to treat autosomal recessive polycystic kidney disease
Official title: Investigation of urinary extracellular vesicles as novel and safe therapeutics for autosomal recessive polycystic kidney disease
Funded at University of Southern California · NIH-10750704 · Data updated 2026-11-12
This study is looking at a new way to help kids with autosomal recessive polycystic kidney disease (ARPKD) by using tiny particles found in urine, which might improve their treatment and overall health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 4, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $465,690 |
| NIH project number | 1R21HD113263-01 |
| Project ID | NIH-10750704 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autosomal recessive polycystic kidney disease, particularly those experiencing severe symptoms.
✕Less likely to help
Patients with other forms of kidney disease or those who do not have autosomal recessive polycystic kidney disease may not benefit from this research.
What this research studies
This research investigates the use of urinary extracellular vesicles (uEVs) as a potential new therapy for autosomal recessive polycystic kidney disease (ARPKD), a serious condition that can lead to kidney failure in children. The study aims to explore how these tiny biological particles, which are involved in cell communication, can be harnessed to improve treatment outcomes for patients with ARPKD. By focusing on the safety and efficacy of uEVs, the research seeks to provide a novel approach to therapy that could address the limitations of existing treatments. Patients may be involved in clinical trials to evaluate the effectiveness of this innovative therapy.
Why it matters
Potential benefit: If successful, this research could lead to a new, safe treatment option for patients with autosomal recessive polycystic kidney disease.
How similar studies have gone: While the use of urinary extracellular vesicles is a novel approach, similar strategies in other conditions have shown promise, indicating potential for success in this area.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Chung, Eun Ji Paige — University of Southern California
- Study coordinator: Chung, Eun Ji Paige
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.