Using ultrasound to enhance the delivery of anti-inflammatory therapies through engineered extracellular vesicles
Ultrasound-assisted extracellular vesicle engineering and induced release: EVEiR
This study is exploring a new way to deliver medicine for chronic inflammatory diseases by using ultrasound to boost tiny carriers called extracellular vesicles, which can help transport helpful treatments directly to where they're needed in the body, potentially leading to better outcomes for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10875655 on NIH RePORTER |
What this research studies
This research focuses on improving drug delivery systems for chronic inflammatory diseases by utilizing ultrasound to enhance the production and effectiveness of extracellular vesicles (EVs). These EVs are natural carriers that can transport therapeutic agents, such as the anti-inflammatory cytokine IL10, to targeted areas in the body. The study aims to develop a novel platform called EVEiR, which uses ultrasound stimulation to increase the efficiency of EV production and their therapeutic potential in an in vitro intestinal model. Patients may benefit from more effective treatments for chronic inflammatory diseases through this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic inflammatory diseases who are seeking new treatment options.
Not a fit: Patients with acute inflammatory conditions or those not affected by chronic inflammatory diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective therapies for patients suffering from chronic inflammatory diseases.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles for drug delivery, but this specific approach using ultrasound is relatively novel.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Kanada, Masamitsu — Michigan State University
- Study coordinator: Kanada, Masamitsu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.