Using ultrasound to control protein expression in 3D cell cultures
Official title: Genetically Manipulating Protein Expression to Probe 3D Cell Behavior using Ultrasound-Responsive Biomaterials
Funded at Oregon Health & Science University · NIH-10912617 · Data updated 2026-11-12
This study is exploring new ways to use sound waves to help control how cells behave in 3D environments, which could lead to better treatments for diseases and help with healing damaged tissues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $383,107 |
| NIH project number | 5R35GM151057-02 |
| Project ID | NIH-10912617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from advanced regenerative therapies, such as tissue damage or degenerative diseases.
✕Less likely to help
Patients with stable conditions that do not require regenerative therapies or those who are not candidates for experimental treatments may not benefit from this research.
What this research studies
This research focuses on developing innovative biomaterials that allow for the controlled manipulation of protein expression in three-dimensional cell cultures. By using ultrasound technology, researchers aim to noninvasively induce gene expression and gene editing at specific times and locations within these 3D scaffolds. This approach will help to recreate complex biological processes, enhancing our understanding of cell behavior and interactions, which is crucial for advancing regenerative therapies. The goal is to model disease states and facilitate tissue repair through improved control of cellular functions.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine and improved therapies for various diseases by enhancing our understanding of cell behavior.
How similar studies have gone: While the approach of using ultrasound for genetic manipulation in 3D cultures is innovative, similar techniques have shown promise in other areas of biomedical research, suggesting potential for success.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Ibsen, Carolyn Schutt — Oregon Health & Science University
- Study coordinator: Ibsen, Carolyn Schutt
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.