Using ultrasound to control protein expression in 3D cell cultures
Genetically Manipulating Protein Expression to Probe 3D Cell Behavior using Ultrasound-Responsive Biomaterials
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10912617
This study is exploring new ways to use sound waves to help control how cells behave in 3D environments, which could lead to better treatments for diseases and help with healing damaged tissues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10912617 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative biomaterials that allow for the controlled manipulation of protein expression in three-dimensional cell cultures. By using ultrasound technology, researchers aim to noninvasively induce gene expression and gene editing at specific times and locations within these 3D scaffolds. This approach will help to recreate complex biological processes, enhancing our understanding of cell behavior and interactions, which is crucial for advancing regenerative therapies. The goal is to model disease states and facilitate tissue repair through improved control of cellular functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from advanced regenerative therapies, such as tissue damage or degenerative diseases.
Not a fit: Patients with stable conditions that do not require regenerative therapies or those who are not candidates for experimental treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine and improved therapies for various diseases by enhancing our understanding of cell behavior.
How similar studies have performed: While the approach of using ultrasound for genetic manipulation in 3D cultures is innovative, similar techniques have shown promise in other areas of biomedical research, suggesting potential for success.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IBSEN, CAROLYN SCHUTT — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: IBSEN, CAROLYN SCHUTT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.