Using ultrasound and microbubbles to improve heart recovery after a heart attack
Ultrasound Targeted Microbubble Cavitation to Treat Coronary Microvascular Obstruction
This study is exploring a new way to help people recover from heart attacks by using special ultrasound techniques to improve blood flow and heart function, which could lower the chances of developing heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11082270 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treat coronary microvascular obstruction (MVO) that can occur after a heart attack. By using ultrasound targeted microbubble cavitation, the study aims to enhance blood flow and improve heart function by increasing the availability of nitric oxide, a key molecule for heart recovery. Patients may benefit from this technique as it could lead to better outcomes following acute myocardial infarction, particularly in reducing the risk of congestive heart failure. The methodology involves non-invasive ultrasound techniques combined with microbubbles to stimulate blood vessel function and promote healing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced an acute myocardial infarction and are at risk for coronary microvascular obstruction.
Not a fit: Patients who have not experienced a heart attack or those with advanced heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve recovery and reduce heart failure risk for patients who have suffered a heart attack.
How similar studies have performed: Previous research has shown promising results using similar ultrasound techniques to enhance heart recovery, indicating potential for success in this approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Pacella, John J — University of Pittsburgh at Pittsburgh
- Study coordinator: Pacella, John J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.