Using ultrasound and microbubbles to improve drug delivery to brain tumors
TRANSCRANIAL FUS THERAPY WITH CLOSED-LOOP US IMAGE GUIDANCE AND CIRCULATING
This study is exploring how using ultrasound with tiny bubbles can help deliver medicine more effectively to the brain, which is important for treating brain tumors, and it aims to create a smart system that adjusts the treatment for better results while keeping you safe.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10977875 on NIH RePORTER |
What this research studies
This research investigates how ultrasound combined with circulating microbubbles can enhance the delivery of therapeutic agents across the blood-brain barrier, which is a significant challenge in treating brain tumors. By applying ultrasound, the microbubbles create mechanical stress in blood vessels, temporarily increasing the permeability of the blood-brain barrier and allowing for better drug accumulation in the brain. The study aims to develop a closed-loop system that can fine-tune the ultrasound parameters to optimize treatment while minimizing safety risks. This innovative approach could lead to more effective therapies for patients with brain tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with brain tumors who require more effective treatment options.
Not a fit: Patients with conditions unrelated to brain tumors or those who do not require drug delivery across the blood-brain barrier may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the effectiveness of cancer treatments for brain tumors by enhancing drug delivery while reducing side effects.
How similar studies have performed: Previous research has shown promise in using ultrasound and microbubbles for drug delivery, indicating that this approach has potential for success.
Where this research is happening
Atlanta, United States
- Georgia Institute of Technology — Atlanta, United States (Active)
Researchers
- Principal investigator: Arvanitis, Konstantinos-Costas — Georgia Institute of Technology
- Study coordinator: Arvanitis, Konstantinos-Costas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.