Using tumor genomics to improve immune-based cancer treatment
Immunogenomics platform for the analysis of cancer
['FUNDING_OTHER'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11192793
This project uses patients' tumor genetic data to learn how immune-based cancer therapies work better for different people with cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11192793 on ClinicalTrials.gov |
What this research studies
I would share that the team builds and runs a computational platform that analyzes tumor sequencing from people with cancer to find immune-related signals. They combine genetic data with clinical information to look for patterns that predict who benefits from immunotherapies across cancer types. The work is done at the Cleveland Clinic and supports multiple NCI-funded projects that already use patient tumor samples and sequencing. Results aim to move discoveries from the computer into tests or markers that could guide patient care.
Who could benefit from this research
Good fit: Ideal candidates would be people with cancer who have had tumor genetic testing or who are willing to contribute tumor samples and clinical data for research.
Not a fit: People without cancer, those who cannot provide tumor samples or data, or those seeking an immediate change to their care are unlikely to benefit directly from this grant.
Why it matters
Potential benefit: If successful, this work could help match patients to the immune-based treatments most likely to help them and avoid ineffective therapies.
How similar studies have performed: Related computational immunogenomics efforts have identified biomarkers like high tumor mutation burden that helped guide FDA approvals for immunotherapy, showing real-world promise.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAKAROV, VLADIMIR — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: MAKAROV, VLADIMIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Patient, Cancers