Using tongue exercises to improve swallowing and breathing in motor neuron diseases
Harnessing tongue exercise to enhance neuroplasticity and preserve upper airway function in a novel model of hypoglossal motor neuron degeneration
This study is looking at how tongue exercises might help people with motor neuron diseases like ALS breathe and swallow better by keeping their throat muscles strong and coordinated.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10673603 on NIH RePORTER |
What this research studies
This research investigates how tongue exercises can help maintain upper airway function in patients with motor neuron diseases like ALS. It focuses on understanding the degeneration of hypoglossal motor neurons and how this affects swallowing and breathing. The study employs a novel model that mimics motor neuron death and assesses the impact of tongue exercises on muscle strength and coordination. By exploring these exercises, the research aims to find effective interventions for improving daily living functions in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with motor neuron diseases such as amyotrophic lateral sclerosis (ALS) who experience difficulties with swallowing and breathing.
Not a fit: Patients with motor neuron diseases who do not exhibit swallowing or breathing difficulties may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved swallowing and breathing capabilities for patients with motor neuron diseases.
How similar studies have performed: Previous pilot studies have shown promising results with tongue exercises preserving muscle strength and function in similar models, indicating potential for success in this approach.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Nichols, Nicole L. — University of Missouri-Columbia
- Study coordinator: Nichols, Nicole L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.