Using TNFα modulation to treat Alzheimer's disease and related dementia
Modulation of TNFα as a Treatment for Alzheimer's Disease and Related Dementia
This study is looking at how a substance called TNFα might help improve brain health and thinking skills in older adults with Alzheimer's and other types of dementia, especially those who also have conditions like diabetes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10511026 on NIH RePORTER |
What this research studies
This research investigates the role of Tumor Necrosis Factor alpha (TNFα) in treating Alzheimer's disease and related dementias. It focuses on how metabolic and vascular health impact cognitive function in older adults, particularly those with comorbid conditions like diabetes. The study aims to explore whether modulating the TNFα pathway can improve brain metabolism and vascular health, potentially reducing the risk of cognitive decline. Patients may be monitored for changes in cognitive function and overall health as part of the research.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 21 and above who are experiencing cognitive impairment or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve cognitive function and quality of life for patients with Alzheimer's disease.
How similar studies have performed: While there have been studies targeting metabolic and vascular health in dementia, the specific approach of modulating TNFα is relatively novel and has not been extensively tested.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Territo, Paul Richard — Indiana University Indianapolis
- Study coordinator: Territo, Paul Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.