Using tissue chips to improve treatment for a rare heart condition in children
Official title: Tissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardia
Funded at Boston Children's Hospital · NIH-10914830 · Data updated 2026-11-12
This study is looking at how tiny tissue models made from kids' own cells can help find the best treatments for catecholaminergic polymorphic ventricular tachycardia (CPVT), so doctors can offer safer and more personalized care without putting them through risky trials.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $827,138 |
| NIH project number | 5UH3TR003279-05 |
| Project ID | NIH-10914830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with catecholaminergic polymorphic ventricular tachycardia.
✕Less likely to help
Patients with other types of arrhythmias or those not diagnosed with CPVT may not benefit from this research.
What this research studies
This research investigates how patient-specific tissue chips can predict the effectiveness of treatments for catecholaminergic polymorphic ventricular tachycardia (CPVT), a serious heart condition in children. By creating tissue models from individual patients, the study aims to identify the best therapeutic options without exposing patients to the risks of traditional clinical trials. The approach focuses on understanding how different patients respond to treatments, which could lead to more personalized and effective care for those with CPVT.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment options for children suffering from CPVT.
How similar studies have gone: Previous research has shown promise in using tissue chips for personalized medicine, indicating potential success for this novel approach.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Pu, William Tswenching — Boston Children's Hospital
- Study coordinator: Pu, William Tswenching
Related research
Other NIH-funded projects on the same topics.
-
Map heart tissue to guide VT ablation with AI help
A patient-oriented project aims to use AI-based mapping to better identify abnormal heart tissue responsible for ventricular tachycardia and guide safer, faster ablation.
-
Proton SBRT for refractory ventricular tachycardia with real-time 3D/4D imaging
A patient-facing study exploring a proton-based, noninvasive radiation therapy to treat stubborn VT using advanced 3D and 4D imaging to target the heart safely.
-
Venous ethanol ablation to treat ischemic VT (VE-VT)
A new treatment approach uses ethanol delivered through heart veins to help stop dangerous heart rhythms in patients with previous heart damage.
-
Novel gene therapy tools to prevent dangerous heart rhythms
A small grant supports testing gene-therapy methods to stop ventricular tachycardia after a heart attack, with the goal of helping people at risk of sudden heart rhythm problems.
-
Radiation-guided ablation for ventricular tachycardia
This project tests a noninvasive radiation approach to ablate heart tissue in people with dangerous ventricular tachycardia to reduce the need for invasive procedures.
-
Low-Field MRI–Guided Robotic Catheter System for VT Ablation
A research project is testing a new low-field MRI–guided robotic catheter to improve treatment of ventricular tachycardia for patients with abnormal heart structure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.