Using text reminders and financial rewards to help adults take their antidepressants

Testing tailored text reminders and financial incentives to enhance antidepressant adherence for depressed adults in primary care

NIH-funded research University of Pennsylvania · NIH-11166652

This study is looking at whether sending personalized text message reminders and offering small cash rewards can help adults stick to their antidepressant medications better, and it’s for people who have recently started taking these medications.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-11166652 on NIH RePORTER

What this research studies

This research investigates how personalized text message reminders and small financial incentives can improve adherence to antidepressant medications among adults in primary care. The study will involve 525 participants who have recently been prescribed antidepressants, comparing the effectiveness of reminders alone versus reminders combined with financial rewards. Adherence will be monitored using wireless pill bottles and electronic health records, while depression symptoms will be assessed through phone interviews. The goal is to find the most effective and cost-efficient way to support patients in maintaining their medication routines.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 years old who have been newly prescribed antidepressant medications and are experiencing depression.

Not a fit: Patients who are not currently prescribed antidepressants or those with severe mental health conditions requiring immediate intervention may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved adherence to antidepressant medications, resulting in better mental health outcomes for patients.

How similar studies have performed: Previous research has shown that behavioral interventions, including reminders and incentives, can effectively improve medication adherence, suggesting this approach may yield positive results.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.