Using tesamorelin with exercise to improve physical function in people with HIV
Official title: Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH)
Funded at Massachusetts General Hospital · NIH-10923120 · Data updated 2026-11-12
This study is looking at whether taking tesamorelin along with exercise can help people living with HIV feel stronger and improve their overall health, especially since they often deal with issues like aging and weakness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $697,594 |
| NIH project number | 1R01AG087809-01 |
| Project ID | NIH-10923120 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who experience impaired physical function and frailty.
✕Less likely to help
Patients who are not living with HIV or those who do not have issues related to physical function or frailty may not benefit from this research.
What this research studies
This research investigates the effects of tesamorelin, a growth hormone-releasing hormone analogue, when combined with exercise to enhance physical function in individuals living with HIV. The study aims to address the challenges faced by these individuals, who often experience accelerated aging and frailty despite modern antiretroviral therapies. By testing this combination approach, the research seeks to determine if tesamorelin can improve the biological and clinical responses to exercise, ultimately enhancing quality of life. Participants will engage in a clinical trial that includes supervised exercise sessions alongside the administration of tesamorelin.
Why it matters
Potential benefit: If successful, this research could significantly improve physical function and quality of life for individuals living with HIV.
How similar studies have gone: Previous research has shown promising results with similar pharmacologic approaches in enhancing exercise responses in other populations, suggesting potential for success in this novel application.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Fourman, Lindsay Tara — Massachusetts General Hospital
- Study coordinator: Fourman, Lindsay Tara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.