Using targeted techniques to protect tongue muscles in ALS
Targeted neuromodulation strategies to delay hypoglossal motoneuron death and preserve tongue strength, function, and structure in a mouse model of ALS
This study is looking at a new way to help keep important tongue-moving nerve cells alive in people with ALS, which can help make swallowing easier and improve their quality of life.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10527999 on NIH RePORTER |
What this research studies
This research investigates how to prevent the death of specific neurons that control tongue movement in patients with amyotrophic lateral sclerosis (ALS), which often leads to severe swallowing difficulties. The team will use a mouse model to test a novel treatment involving optogenetic stimulation, a method that uses light to activate neurons and promote their survival and function. By focusing on preserving tongue strength and function, the research aims to improve the quality of life for ALS patients who struggle with dysphagia, a common and debilitating symptom of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis who are experiencing swallowing difficulties.
Not a fit: Patients who do not have ALS or those who are not experiencing dysphagia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve swallowing function and overall survival for ALS patients.
How similar studies have performed: While the approach of using optogenetic stimulation is innovative, similar techniques have shown promise in other neurological conditions, suggesting potential for success in this context.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Lever, Teresa E — University of Missouri-Columbia
- Study coordinator: Lever, Teresa E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.