Using targeted radiation and immunotherapy to treat certain cancers
Targeted radiation and immunocytokine therapy for CEA positive malignancies
This study is looking at a new way to treat certain cancers by using a mix of targeted radiation and a special immune therapy to help your body fight the tumor better, and it's for patients whose cancers have a specific marker called CEA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10932893 on NIH RePORTER |
What this research studies
This research investigates a combination of image-guided radiotherapy and targeted immunotherapy to improve treatment outcomes for cancers that express the carcinoembryonic antigen (CEA). The approach aims to modify the tumor microenvironment to make tumors more susceptible to immune attack. Patients will receive targeted radiation followed by immunocytokine therapy, which is designed to enhance the immune response against the tumor. The research includes clinical trials that will assess the effectiveness of this treatment in increasing immune cell infiltration into tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cancers that express carcinoembryonic antigen, such as colon or breast cancer.
Not a fit: Patients with cancers that do not express carcinoembryonic antigen or those who are not eligible for radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with CEA-positive malignancies, potentially improving survival rates.
How similar studies have performed: Previous studies have shown promise in using targeted radiation combined with immunotherapy, suggesting that this approach could be effective.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Shively, John Ernest — Beckman Research Institute/city of Hope
- Study coordinator: Shively, John Ernest
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.