Using targeted nano-boron therapy to treat gliomas
Official title: Targeted nano-boron based boron neutron capture therapy for glioma treatment
Funded at Loma Linda University · NIH-10600003 · Data updated 2026-11-12
This study is testing a new way to treat aggressive brain tumors called gliomas by using a special nanodrug that helps deliver a targeted treatment directly to the cancer cells while protecting healthy tissue, making it a friendlier option for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | May 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $158,828 |
| NIH project number | 5R21CA259911-03 |
| Project ID | NIH-10600003 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with gliomas who have not responded well to conventional treatments.
✕Less likely to help
Patients with non-glioma brain tumors or those who are not eligible for BNCT may not benefit from this research.
What this research studies
This research focuses on developing a new treatment for gliomas, which are aggressive brain tumors. It utilizes boron neutron capture therapy (BNCT), a noninvasive method that targets cancer cells while minimizing damage to surrounding healthy tissue. The approach involves creating a specialized nanodrug that can effectively cross the blood-brain barrier and deliver a high concentration of Boron-10 directly to glioma cells. By enhancing the delivery of this active drug, the research aims to improve treatment outcomes for patients with this challenging condition.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and quality of life for patients with gliomas.
How similar studies have gone: While BNCT has shown promise in other contexts, this specific approach using targeted nano-boron therapy is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Patil, Rameshwar Tukaram — Loma Linda University
- Study coordinator: Patil, Rameshwar Tukaram
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.